Details of the Drug

General Information of Drug (ID: DM09FOQ)

• Drug Name: Pyrido[1,2-a]indole-1.-carboxylic acid analog 4
• Synonyms: PMID25468267-Compound-37
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 294.3
  Logarithm of the Partition Coefficient (xlogp); 3.3
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C18H18N2O2
  IUPAC Name: 1-(3-acetylpyrido[1,2-a]indol-10-yl)-2-(dimethylamino)ethanone
  Canonical SMILES: CC(=O)C1=CC2=C(C=C1)C(=C3N2C=CC=C3)C(=O)CN(C)C
  InChI: InChI=1S/C18H18N2O2/c1-12(21)13-7-8-14-16(10-13)20-9-5-4-6-15(20)18(14)17(22)11-19(2)3/h4-10H,11H2,1-3H3
  InChIKey: QISRGBAMCCXAKB-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 66667765
  TTD ID: D02FWO

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysine-specific demethylase 4C (KDM4C)	TTV8CRH	KDM4C_HUMAN	Inhibitor	[1]

References

• [1] KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.