Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Clearance: The apparent oral clearance of drug is 1007 mL/min [1]
  Elimination: Approximately 70% of an administered dose is excreted as metabolites in the urine and more than 16% in the feces within 5 days [2]
  Half-life: The concentration or amount of drug in body reduced by one-half in 2.8 - 7.4 hours [2]
  Metabolism: The drug is metabolized via the liver [3]
  Vd: The volume of distribution (Vd) of drug is 300 L [4]

References

• [1] Busse D, Fromm MF, Morike K, Drescher S, Kuhlkamp V, Eichelbaum M: Disposition and pharmacologic effects of R/S-verapamil in patients with chronic atrial fibrillation: an investigation comparing single and multiple dosing. Clin Pharmacol Ther. 2001 May;69(5):324-32. doi: 10.1067/mcp.2001.115125.
• [2] Verapamil FDA Label
• [3] Rodriguez-Gascon A, Canut-Blasco A: Deciphering pharmacokinetics and pharmacodynamics of fosfomycin. Rev Esp Quimioter. 2019 May;32 Suppl 1:19-24.
• [4] Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. doi: 10.1111/j.1526-4610.2008.01298.x.