Details of the Drug

General Information of Drug (ID: DM0HAC8)

Drug Name

Cerliponase Alfa

Synonyms

Brineura

Indication

Disease Entry	ICD 11	Status	REF
Neuronal ceroid lipofuscinosis	5C56.1	Approved	[1]
Tripeptidyl peptidase 1 deficiency	5C50	Approved	[2]
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Drug Type

Recombinant protein

Sequence

SYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVSDPSSPQYGKY
LTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFH
HYVGGPTETHVVRSPHPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLG
VTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVAR
VVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPH
VHTVSYGDDEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFP
ASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPHLPPS
SYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGILSLINEHRILSGRPP
LGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKT
LLNP

ADMET Property

Metabolism: The drug is metabolized via peptide hydrolysis []
Vd: The volume of distribution (Vd) of drug is 0.245 L []

Cross-matching ID

DrugBank ID: DB13173
TTD ID: D06CAS

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tripeptidyl-peptidase I (TPP1)	TTOVYPT	TPP1_HUMAN	Modulator	[3]

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Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018
2	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.