Details of the Drug

General Information of Drug (ID: DM0S2UK)

• Drug Name: US9422240, 1-286
• Synonyms: CHEMBL3899803; SCHEMBL16761915; BDBM242550; US9422240, 1-286
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 426.4
  Logarithm of the Partition Coefficient (xlogp); 2.8
  Rotatable Bond Count (rotbonds); 8
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 7
• Chemical Identifiers:
  Formula: C22H22N2O7
  IUPAC Name: 2-[[4-hydroxy-1-[[4-(3-methoxyphenoxy)phenyl]methyl]-6-oxo-2,3-dihydropyridine-5-carbonyl]amino]acetic acid
  Canonical SMILES: COC1=CC(=CC=C1)OC2=CC=C(C=C2)CN3CCC(=C(C3=O)C(=O)NCC(=O)O)O
  InChI: InChI=1S/C22H22N2O7/c1-30-16-3-2-4-17(11-16)31-15-7-5-14(6-8-15)13-24-10-9-18(25)20(22(24)29)21(28)23-12-19(26)27/h2-8,11,25H,9-10,12-13H2,1H3,(H,23,28)(H,26,27)
  InChIKey: ZKPWKTAYUOZETR-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 73053305
  TTD ID: D0L9XU

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]

References

• [1] Partially saturated nitrogen-containing heterocyclic compound. US9422240.