Details of the Drug

General Information of Drug (ID: DM0UPQJ)

Drug Name

Dotinurad

Synonyms

Dotinurad; 1285572-51-1; FYU-981; Dotinurad [INN]; (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone; 305EB53128; (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone; Urece; Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-; Urece (TN); Dotinurad (JAN/INN); DOTINURAD [JAN]; DOTINURAD [WHO-DD]; FYU981; CHEMBL4594446; SCHEMBL10322525; GTPL11389; VOFLAIHEELWYGO-UHFFFAOYSA-N; UNII-305EB53128; EX-A5737; BDBM50561689; AKOS040741664; HY-109031; CS-0030545; D11071; 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

Indication

Disease Entry	ICD 11	Status	REF
Gout	FA25	Phase 3	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C14H9Cl2NO4S
Canonical SMILES: C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl
InChI: InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChIKey: VOFLAIHEELWYGO-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 51349053
TTD ID: DA29IM

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Urate anion exchanger 1 (URAT1)	TTA592U	S22AC_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT05007392) A Randomized, Multicenter, Double-Blind, Superiority Study of Dotinurad (4 mg) and Febuxostat (40 mg) for the Treatment of Subjects With Gout. U.S.National Institutes of Health.
2	Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout. Expert Opin Pharmacother. 2021 Aug;22(11):1397-1406.