Details of the Drug

General Information of Drug (ID: DM1C4UM)

Drug Name

LAMB3-transduced autologous epidermal stem cells

Synonyms

LAMB3-transduced autologous epidermal stem cells (retroviral vector, junctionalepidermolysis bullosa), University of Modena and Reggio Emilia/Holostem; LAMB3-transduced autologous epidermal stem cells (ZFN-mediated transduction, epidermolysis bullosa), University of Modena and Reggio Amilia/San Raffaele-Telethon Institute for Gene Therapy/Sangamo

Indication

Disease Entry	ICD 11	Status	REF
Epidermolysis bullosa	EC3Z	Phase 1	[1]
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Cross-matching ID

TTD ID: D09PFR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Laminin beta-3 chain (LAMB3)	TT2WOUQ	LAMB3_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Long-Term Stability and Safety of Transgenic Cultured Epidermal Stem Cells in Gene Therapy of Junctional Epidermolysis Bullosa. Stem Cell Reports. 2014 January 14; 2(1): 1-8.
2	Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402.