| Drug Name |
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| Synonyms |
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| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
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| Logarithm of the Partition Coefficient (xlogp) |
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| Rotatable Bond Count (rotbonds) |
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| Hydrogen Bond Donor Count (hbonddonor) |
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| Hydrogen Bond Acceptor Count (hbondacc) |
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| ADMET Property |
- Absorption Tmax
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The time to maximum plasma concentration (Tmax) is 1-2 h
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- Clearance
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The apparent oral clearance of drug is 6.45 L/h
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- Elimination
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64.7% of talazoparib is excreted in the urine with 54.6% as unchanged drug, and 19.7% is eliminated in the feces with 13.6% as unchanged drug
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- Half-life
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The concentration or amount of drug in body reduced by one-half in 90 hours
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- Metabolism
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The drug is metabolized via the mono-oxidation, dehydrogenation, cysteine conjugation of a mono-desfluoro metabolite, and glucuronide conjugation
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- Vd
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The volume of distribution (Vd) of drug is 420 L
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| Cross-matching ID |
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