General Information of Drug (ID: DM2QBHP)

Drug Name
Eteplirsen
Synonyms AVI-4658
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Approved [1]
Drug Type
Antisense drug
Sequence
CUCCAACAUCAAGGAAGAUGGCAUUUCUAG
Structure 3D Structure is Not Available
3D MOL is unavailable 2D MOL
ADMET Property
Clearance
The total clearance of drug is 339 mL/h/kg []
Half-life
The concentration or amount of drug in body reduced by one-half in 3.3 hours [2]
Metabolism
The drug is metabolized via the hepatic []
Vd
The volume of distribution (Vd) of drug is 0.6 L/kg []
Cross-matching ID
DrugBank ID
DB06014
TTD ID
D04AIV

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dystrophin messenger RNA (DMD mRNA) TTWLFXU DMD_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Duchenne dystrophy
ICD Disease Classification 8C70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dystrophin messenger RNA (DMD mRNA) DTT DMD 1.15E-07 -1.07 -2.94
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds