Details of the Drug

General Information of Drug (ID: DM3XWMO)

• Drug Name: US8598210, Table XV, 4
• Synonyms: US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridine-2- carbonyl)amino]-acetic acid; SCHEMBL1923034; CHEMBL3646215; BDBM107698; US8598210, Table XV, 4
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 286.28
  Logarithm of the Partition Coefficient (xlogp); 2.2
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C15H14N2O4
  IUPAC Name: 2-[[3-hydroxy-5-(4-methylphenyl)pyridine-2-carbonyl]amino]acetic acid
  Canonical SMILES: CC1=CC=C(C=C1)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
  InChI: InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
  InChIKey: VBNCAZJDNCXKIO-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 24891734
  TTD ID: D01XZT

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]

References

• [1] Prolyl hydroxylase inhibitors and methods of use. US8598210.