Details of the Drug

General Information of Drug (ID: DM4MF9V)

Drug Name
proglumide
Synonyms Milid; Nulsa; W-5219
Indication
Disease Entry ICD 11 Status REF
Influenza virus infection 1E30-1E32 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 334.4
Logarithm of the Partition Coefficient (xlogp) 2.4
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C18H26N2O4
IUPAC Name
4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
Canonical SMILES
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
InChIKey
DGMKFQYCZXERLX-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4922
ChEBI ID
CHEBI:32058
CAS Number
6620-60-6
DrugBank ID
DB13431
TTD ID
D04HQT

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholecystokinin receptor type A (CCKAR) TTCG0AL CCKAR_HUMAN Antagonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Influenza virus infection
ICD Disease Classification 1E30-1E32
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholecystokinin receptor type A (CCKAR) DTT CCKAR 9.99E-01 -0.03 -0.2
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung. 1987 Nov;37(11):1265-8.