Details of the Drug

General Information of Drug (ID: DM4O6I5)

• Drug Name: 5-Iodouracil
• Synonyms: 5-Iodouracil; 696-07-1; 5-iodopyrimidine-2,4(1H,3H)-dione; 2,4(1H,3H)-Pyrimidinedione, 5-iodo-; 5-iodopyrimidine-2,4-diol; Uracil, 5-iodo-; 2,4-Dihydroxy-5-iodopyrimidine; 5-iodo-1H-pyrimidine-2,4-dione; 5-iodo uracil; UNII-H59BRK500M; NSC 57848; CHEBI:43636; EINECS 211-788-2; CHEMBL1173; AI3-50390; H59BRK500M; KSNXJLQDQOIRIP-UHFFFAOYSA-N; 5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione; NSC57848; MFCD00006020; 5-Iodouracil, 99%; 5-iodo-1,3-dihydropyrimidine-2,4-dione; IUR; 5909-21-7; 5-Iodo-uracil; 5- Iodouracil; zlchem 530

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 237.98
  Logarithm of the Partition Coefficient (xlogp); 0
  Rotatable Bond Count (rotbonds); 0
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C4H3IN2O2
  IUPAC Name: 5-iodo-1H-pyrimidine-2,4-dione
  Canonical SMILES: C1=C(C(=O)NC(=O)N1)I
  InChI: InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
  InChIKey: KSNXJLQDQOIRIP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 69672
  ChEBI ID: CHEBI:43636
  CAS Number: 696-07-1
  DrugBank ID: DB03554
  TTD ID: D08EZR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.