Details of the Drug

General Information of Drug (ID: DM4V6JE)

• Drug Name: 1H-Pyrazole-3-carboxylic acid
• Synonyms: 1H-Pyrazole-3-carboxylic acid; 1621-91-6; Pyrazole-3-carboxylic acid; 1H-Pyrazole-5-carboxylic acid; 2H-PYRAZOLE-3-CARBOXYLIC ACID; 5-Pyrazolecarboxylic acid; 3-Pyrazolecarboxylic acid; 797027-83-9; 3-carboxy-1h-pyrazole; Pyrazolic acid; CHEMBL128679; KOPFEFZSAMLEHK-UHFFFAOYSA-N; pyrazolecarboxylic; 3-Carboxypyrazole; 2H-PYRAZOLE-3-CARBOXYLICACID; zlchem 656; pyrazolecarboxylic acid; pyrazole-5-carboxylic; PubChem12935; AC1Q5UBI; AC1LCCJ7; 3-pyrazole carboxylic acid; pyrazole 3-carboxylic acid; ACMC-209z0p; Pyrazole-5-carboxylic a

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 112.09
  Logarithm of the Partition Coefficient (xlogp); 0.1
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C4H4N2O2
  IUPAC Name: 1H-pyrazole-5-carboxylic acid
  Canonical SMILES: C1=C(NN=C1)C(=O)O
  InChI: InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8)
  InChIKey: KOPFEFZSAMLEHK-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 574310
  CAS Number: 1621-91-6
  TTD ID: D0M7DC

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinic acid receptor (HCAR2)	TTWNV8U	HCAR2_HUMAN	Inhibitor	[1]

References

• [1] Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51.