Details of the Drug

General Information of Drug (ID: DM5W0A2)

• Drug Name: US8481586, 5
• Synonyms: CHEMBL573176; SCHEMBL844935; BDBM50299248; US8481586, 5; 1,10-Dihydropyrrolo[2,3-a]carbazole-3-carboxamide
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 249.27
  Logarithm of the Partition Coefficient (xlogp); 2.4
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 1
• Chemical Identifiers:
  Formula: C15H11N3O
  IUPAC Name: 1,10-dihydropyrrolo[2,3-a]carbazole-3-carboxamide
  Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C4=C(C=C3)C(=CN4)C(=O)N
  InChI: InChI=1S/C15H11N3O/c16-15(19)11-7-17-13-10(11)6-5-9-8-3-1-2-4-12(8)18-14(9)13/h1-7,17-18H,(H2,16,19)
  InChIKey: MXZKCOUOYWSEKW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 44479711
  TTD ID: D0NE0N

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PIM-3 protein kinase (PIM3)	TTCGOIN	PIM3_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
PIM-3 protein kinase (PIM3)	DTT	PIM3	7.86E-06	0.78	3.44

References

• [1] Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586.