Details of the Drug

General Information of Drug (ID: DM6NIZD)

Drug Name

Gilotrif

Synonyms

Afatinib dimaleate; AFATINIB DIMALEATE; 850140-73-7; Afatinib (diMaleate); UNII-V1T5K7RZ0B; BIBW 2992MA2; Afatinib dimaleate [USAN]; V1T5K7RZ0B; CHEBI:76003; Afatinib (BIBW2992) Dimaleate; Afatinib maleate; Afatinib dimaleate (USAN); Giotrif; Gilotrif (TN); Giotrif (TN); Afatinib maleate (JAN); (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate); BIBW2992 MA2; CHEMBL2105712; USNRYVNRPYXCSP-JUGPPOIOSA-N; MolPort-028-744-902; AOB873

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 3	[1]
Squamous cell carcinoma	2B60-2D01	Phase 3	[1]
Glioma	2A00.0	Phase 2	[1]
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Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C32H33ClFN5O11
Canonical SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
InChI: 1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1
InChIKey: USNRYVNRPYXCSP-JUGPPOIOSA-N

Cross-matching ID

PubChem CID: 15606394
ChEBI ID: CHEBI:76003
CAS Number: 850140-73-7
TTD ID: D0BD9K

Repurposed Drugs (RPD)

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)