Details of the Drug

General Information of Drug (ID: DM6W9YM)

Drug Name

TP-023

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Preclinical	[1]
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Therapeutic Class

Psychiatric

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Anxiety disorder

ICD Disease Classification

6B00-6B0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate receptor AMPA (GRIA)	DTT	NO-GeName	1.79E-04	-0.69	-0.58

Molecular Expression Atlas (MEA)

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References

1	Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function. Future Med Chem. 2011 February; 3(2): 243-250.
2	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.