Details of the Drug

General Information of Drug (ID: DM7PCLY)

Drug Name
ARC1779
Indication
Disease Entry ICD 11 Status REF
Intracranial embolism 8B22.1 Phase 2 [1]
Drug Type
Small molecular drug
Cross-matching ID
TTD ID
DH8FY6

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
von Willebrand factor (VWF) TT3SZBT VWF_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Intracranial embolism
ICD Disease Classification 8B22.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
von Willebrand factor (VWF) DTT VWF 2.96E-01 2.47 2.08
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT00742612) Effect of ARC1779 on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy. U.S. National Institutes of Health.
2 Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2028-2037.