General Information of Drug (ID: DM84YCI)

Drug Name
12-(3-Adamantan-1-yl-ureido)-dodeca noic acid
Synonyms
AUDA; 479413-70-2; CHEMBL215387; Urea-based compound, 18; 12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid; MLS002415562; SCHEMBL120588; CTK8F0781; BDBM25737; DTXSID20435153; HMS3650M09; HMS2204E15; HMS3332K06; AUDA, > ZINC27645646; MFCD12912267; 1631AH; SMR001339077; ACM479413702; RT-011342; 12-(3-adamantan-1-yl-ureido)-dodecanoic acid; SR-01000860315; SR-01000860315-2; 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 392.6
Logarithm of the Partition Coefficient (xlogp) 5.9
Rotatable Bond Count (rotbonds) 13
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C23H40N2O3
IUPAC Name
12-(1-adamantylcarbamoylamino)dodecanoic acid
Canonical SMILES
C1C2CC3CC1CC(C2)(C3)NC(=O)NCCCCCCCCCCCC(=O)O
InChI
InChI=1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)
InChIKey
XLGSEOAVLVTJDH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10069117
CAS Number
479413-70-2
TTD ID
D0S0SH

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Soluble epoxide hydrolase (EPHX2) TT7WVHI HYES_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Soluble epoxide hydrolase (EPHX2) DTT EPHX2 8.78E-01 -0.1 -0.27
Soluble epoxide hydrolase (EPHX2) DTT EPHX2 4.40E-02 -0.18 -0.42
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem. 2009 Aug 27;52(16):5009-12.