Details of the Drug

General Information of Drug (ID: DM8LRU2)

Drug Name
Revolade/Promacta
Synonyms AC1OC7GM
Indication
Disease Entry ICD 11 Status REF
Idiopathic thrombocytopenic purpura 3B64.10 Approved [1]
Chronic liver disease DB99.0 Phase 3 [1]
Thrombocytopenia 3B64 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 330.9
Topological Polar Surface Area (xlogp) 9.3
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 0
Chemical Identifiers
Formula
C22H31Cl
IUPAC Name
[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]cycloheptane
Canonical SMILES
C1CCCC(CC1)C/C=C\\C2=CC(=C(C=C2)C3CCCCC3)Cl
InChI
InChI=1S/C22H31Cl/c23-22-17-19(12-8-11-18-9-4-1-2-5-10-18)15-16-21(22)20-13-6-3-7-14-20/h8,12,15-18,20H,1-7,9-11,13-14H2/b12-8-
InChIKey
NDXQJQCGBAIFER-WQLSENKSSA-N
Cross-matching ID
PubChem CID
6913084
TTD ID
D08VSI

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thrombopoietin receptor (MPL) TTIHYA4 TPOR_HUMAN Agonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Idiopathic thrombocytopenic purpura
ICD Disease Classification 3B64.10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thrombopoietin receptor (MPL) DTT MPL 2.61E-06 0.1 0.45
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022291.
2 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
3 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
4 Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
5 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722).
7 A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.