Details of the Drug

General Information of Drug (ID: DM8U8KU)

Drug Name
NI006
Indication
Disease Entry ICD 11 Status REF
Amyloid transthyretin cardiomyopathy 5D00.20 Phase 1 [1]
Drug Type
Antibody
Cross-matching ID
TTD ID
DZ1W4B

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transthyretin (TTR) TTC1I86 TTHY_HUMAN Not Available [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 ClinicalTrials.gov (NCT04360434) A Phase 1, First-in-Human, Double-Blind, Placebo-Controlled, Multicenter, Single and Multiple Ascending Dose Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy Followed by an Open-Label Extension. U.S.National Institutes of Health.
2 Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid. N Engl J Med. 2023 Jul 20;389(3):239-250.