Details of the Drug

General Information of Drug (ID: DM92X7N)

• Drug Name: ASN002
• Synonyms: POAZPIKWEFFCBP-UHFFFAOYSA-N; GTPL10000; 2-[1-(4-{[4-(4-hydroxypiperazin-1-yl)phenyl]amino}-5-oxo-5H,6H-pyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl]acetonitrile

Indication

Disease Entry	ICD 11	Status	REF
Eczema	EA80-EA89	Phase 2	[1]
Lymphoma	2A80-2A86	Phase 1/2	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]

• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 460.5
  Logarithm of the Partition Coefficient (xlogp); 2.6
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 9
• Chemical Identifiers:
  Formula: C24H28N8O2
  IUPAC Name: 2-[1-[4-[4-(4-hydroxypiperidin-1-yl)anilino]-5-oxo-6H-pyrimido[4,5-d]pyridazin-2-yl]piperidin-4-yl]acetonitrile
  Canonical SMILES: C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
  InChI: InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
  InChIKey: NLFLXLJXEIUQDL-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 71269142
  CAS Number: 1425381-60-7
  TTD ID: D0TG4S
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SYK messenger RNA (SYK mRNA)	TT2HUPM	KSYK_HUMAN	Inhibitor	[2]

Molecular Expression Atlas of This Drug

• The Studied Disease: Eczema
• ICD Disease Classification: EA80-EA89

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
SYK messenger RNA (SYK mRNA)	DTT	SYK	3.05E-05	0.29	0.43

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)