Details of the Drug

General Information of Drug (ID: DM9JCD3)

• Drug Name: N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide
• Synonyms: N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE; CHEMBL324942; N-(3-cyclopropyl-1H-pyrazol-5-yl)benzamide; N5B; 1vyz; AC1L9MPJ; SCHEMBL4314346; BDBM7127; LUCORKWTQSQFFU-UHFFFAOYSA-N; 3-Benzamidoaminopyrazole deriv. 4; DB02647

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 227.26
  Logarithm of the Partition Coefficient (xlogp); 2
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C13H13N3O
  IUPAC Name: N-(5-cyclopropyl-1H-pyrazol-3-yl)benzamide
  Canonical SMILES: C1CC1C2=CC(=NN2)NC(=O)C3=CC=CC=C3
  InChI: InChI=1S/C13H13N3O/c17-13(10-4-2-1-3-5-10)14-12-8-11(15-16-12)9-6-7-9/h1-5,8-9H,6-7H2,(H2,14,15,16,17)
  InChIKey: LUCORKWTQSQFFU-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 449088
  DrugBank ID: DB02647
  TTD ID: D0MK6D

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cyclin-dependent kinase 2 (CDK2)	TT7HF4W	CDK2_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cyclin-dependent kinase 2 (CDK2)	DTT	CDK2	2.28E-06	0.12	0.19

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.