Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Bioavailability: The bioavailability of drug is 25-30% [1]
  Clearance: The clearance of drug is 0.12 L/h/kg []
  Elimination: 94% of drug is excreted in feces (77% as parent compound) and 0.4% of drug excreted in urine []
  Half-life: The concentration or amount of drug in body reduced by one-half in 15 hours []
  Metabolism: The drug is metabolized via the CYP2B6, CYP2C8, and CYP3A4 [1]
  Vd: The volume of distribution (Vd) of drug is 1.4-1.6 L/kg [1]

References

• [1] Yin OQ, Wang Y, Schran H: A mechanism-based population pharmacokinetic model for characterizing time-dependent pharmacokinetics of midostaurin and its metabolites in human subjects. Clin Pharmacokinet. 2008;47(12):807-16. doi: 10.2165/0003088-200847120-00005.