Details of the Drug

General Information of Drug (ID: DMA5DO2)

Drug Name

(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione

Synonyms

(5s)-5-iododihydro-2,4(1h,3h)-pyrimidinedione; IDH; AC1NRBRW; SCHEMBL4316335; DB02303; (5S)-5-iodo-1,3-diazinane-2,4-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

240

Logarithm of the Partition Coefficient (xlogp)

-0.4

Rotatable Bond Count (rotbonds)

0

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

2

Chemical Identifiers

Formula: C4H5IN2O2
IUPAC Name: (5S)-5-iodo-1,3-diazinane-2,4-dione
Canonical SMILES: C1[C@@H](C(=O)NC(=O)N1)I
InChI: InChI=1S/C4H5IN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9)/t2-/m0/s1
InChIKey: YGKCTZPSAOUUMT-REOHCLBHSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.