Details of the Drug

General Information of Drug (ID: DMAFZ84)

Drug Name

PIKAMILONE

Synonyms

N-Nicotinoyl-gamma-aminobutyric acid sodium salt; N-(3-Pyridylcarbonyl)-4-aminobutyric acid sodium salt

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

208.21

Logarithm of the Partition Coefficient (xlogp)

-0.4

Rotatable Bond Count (rotbonds)

5

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

4

Chemical Identifiers

Formula: C10H12N2O3
IUPAC Name: 4-(pyridine-3-carbonylamino)butanoic acid
Canonical SMILES: C1=CC(=CN=C1)C(=O)NCCCC(=O)O
InChI: InChI=1S/C10H12N2O3/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14)
InChIKey: NAJVRARAUNYNDX-UHFFFAOYSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Modulator	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT00940186) Clinical Pharmacokinetics Study on Pikamilone. U.S. National Institutes of Health.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015