Details of the Drug

General Information of Drug (ID: DMAHWLR)

Drug Name

MGD007

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 1/2	[1]
Metastatic colorectal cancer	2B91	Phase 1	[2]
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Drug Type

Monoclonal antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cell surface A33 antigen (GPA33)	TT96HUR	GPA33_HUMAN	Modulator	[3]
T-cell surface glycoprotein CD3 gamma (CD3G)	TTV3XPL	CD3G_HUMAN	Modulator	[3]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Colorectal cancer

ICD Disease Classification

2B91.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cell surface A33 antigen (GPA33)	DTT	GPA33	1.62E-10	-1.19	-5.77

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT03531632) MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801.