Details of the Drug

General Information of Drug (ID: DMB4MJ0)

• Drug Name: US9353089, 327
• Synonyms: CHEMBL2011967; SCHEMBL7536669; SCHEMBL8237937; BDBM234554; BDBM50379882; US9353089, 327
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 371.4
  Logarithm of the Partition Coefficient (xlogp); 3.6
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C23H21N3O2
  IUPAC Name: 2-amino-5-[3-(3-methoxyphenyl)phenyl]-3-methyl-5-phenylimidazol-4-one
  Canonical SMILES: CN1C(=O)C(N=C1N)(C2=CC=CC=C2)C3=CC=CC(=C3)C4=CC(=CC=C4)OC
  InChI: InChI=1S/C23H21N3O2/c1-26-21(27)23(25-22(26)24,18-10-4-3-5-11-18)19-12-6-8-16(14-19)17-9-7-13-20(15-17)28-2/h3-15H,1-2H3,(H2,24,25)
  InChIKey: LRYKHTDVFXMHEH-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 11581511
  TTD ID: D0QX1S

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Plasmepsin 2 (Malaria PLA2)	TTXMNHO	PLM2_PLAFA	Inhibitor	[1]

References

• [1] Compositions and methods for the treatment of malaria. US9353089.