Details of the Drug

General Information of Drug (ID: DMB5JWX)

Drug Name
Pegadricase
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 304.34
Logarithm of the Partition Coefficient (xlogp) -3.4
Rotatable Bond Count (rotbonds) 13
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C13H24N2O6
IUPAC Name
(2S)-2-amino-6-[[4-(2-methoxyethoxy)-4-oxobutanoyl]amino]hexanoic acid
Canonical SMILES
COCCOC(=O)CCC(=O)NCCCC[C@@H](C(=O)O)N
InChI
InChI=1S/C13H24N2O6/c1-20-8-9-21-12(17)6-5-11(16)15-7-3-2-4-10(14)13(18)19/h10H,2-9,14H2,1H3,(H,15,16)(H,18,19)/t10-/m0/s1
InChIKey
PNFORBBPPMQASU-JTQLQIEISA-N
Cross-matching ID
PubChem CID
86278331
CAS Number
1040753-26-1
DrugBank ID
DB15129
TTD ID
D0S3BF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Uric acid (URA) TTZ1SWF NOUNIPROTAC Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018169)
2 Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J Rheumatol. 2002 Sep;29(9):1942-9.