Details of the Drug

General Information of Drug (ID: DMB7CE0)

Drug Name
Insulin
Synonyms
BrioDurance; Insulin (agglomerated vesicle technology, diabetes), Cense Biosciences; Insulin (subcutaneous/nanoparticle/suspension/sustained release formulation, diabetes); Insulin (subcutaneous/nanoparticle/suspension/sustained release formulation, diabetes), Cense Biosciences
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Sequence
>A chain
GIVEQCCTSICSLYQLENYCN
>B chain
FVNQHLCGSHLVEALYLVCGERGFFYTPKT
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Chromosomal abnormalities and abnormal gene carriers Not Available RPS6KA1 OTDOTWU4 [2]
Hypoglycaemia Not Available IAPP OT5Z8ERW [2]
Hypoglycaemia Not Available AVP OTAVZ76K [2]
Hypoglycaemia Not Available AVPR1A OTKR8AFL [2]
Cross-matching ID
TTD ID
D0R6CD
VARIDT ID
DR01205
INTEDE ID
DR2102
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Insulin-degrading enzyme (IDE) DE9OSW8 IDE_HUMAN Substrate [3]
Insulin-degrading enzyme (ide) DE0QGHP A0A0C1JXV9_9BACT Substrate [4], [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Islet amyloid polypeptide (IAPP) OT5Z8ERW IAPP_HUMAN Drug Response [2]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Drug Response [2]
Vasopressin V1a receptor (AVPR1A) OTKR8AFL V1AR_HUMAN Drug Response [2]
Vasopressin-neurophysin 2-copeptin (AVP) OTAVZ76K NEU2_HUMAN Drug Response [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5012).
2 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
3 Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 3;44(17):6513-25.
4 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
5 Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad. Gut Pathog. 2016 Jun 20;8:22.