| Drug Name |
|
| Synonyms |
|
| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
|
|
| Logarithm of the Partition Coefficient (xlogp) |
|
| Rotatable Bond Count (rotbonds) |
|
| Hydrogen Bond Donor Count (hbonddonor) |
|
| Hydrogen Bond Acceptor Count (hbondacc) |
|
| ADMET Property |
- Absorption AUC
-
The area under the plot of plasma concentration (AUC) of drug is 200 mcgh/L
[1]
- Absorption Cmax
-
The maximum plasma concentration (Cmax) of drug is 28 mcg/L
[1]
- Bioavailability
-
The bioavailability of drug is 14%
[1]
- Clearance
-
The total plasma clearance of drug is 625 mL/min
[2]
- Elimination
-
Atorvastatin and its metabolites are mainly eliminated in the bile without enterohepatic recirculation
[]
- Half-life
-
The concentration or amount of drug in body reduced by one-half in 14 hours (atorvastatin), and 30 hours (its metabolites)
[]
- Metabolism
-
The drug is metabolized via the cytochrome P450 3A4 in the intestine and liver
[]
- Vd
-
The volume of distribution (Vd) of drug is 380 L
[]
|
| Cross-matching ID |
|
|
|
|
|
|
|
|
