Details of the Drug

General Information of Drug (ID: DMBVZND)

Drug Name

ONYX-015

Synonyms

Dl1520; E1B-deleted adenovirus (cancer), ONYX

Indication

Disease Entry	ICD 11	Status	REF
Head and neck cancer	2D42	Phase 1	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Head and neck cancer

ICD Disease Classification

2D42

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cellular tumor antigen p53 (TP53)	DTT	TP53	7.01E-01	0.06	0.09

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT00006106) ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer. U.S. National Institutes of Health.
2	Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004 Dec;6(6):611-23.