Details of the Drug

General Information of Drug (ID: )

Drug Name
Synonyms
#Ro5 Violations (Lipinski): 1	Molecular Weight (mw)
	Logarithm of the Partition Coefficient (xlogp)
	Rotatable Bond Count (rotbonds)
	Hydrogen Bond Donor Count (hbonddonor)
	Hydrogen Bond Acceptor Count (hbondacc)
ADMET Property	Clearance The renal clearance of drug is 160 mL/h/kg [] Elimination Following IV administration of tenofovir, approximately 70C80% of the dose is recovered in the urine as unchanged tenofovir within 72 hours of dosing [] Half-life The concentration or amount of drug in body reduced by one-half in 17 hours [] Metabolism The drug is metabolized via the constitutively expressed enzymes in the cell [1] Vd The volume of distribution (Vd) of drug is 1.3 +/- 0.6 L/kg []
Cross-matching ID

References

1	Fromenty B, Freneaux E, Labbe G, Deschamps D, Larrey D, Letteron P, Pessayre D: Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem Pharmacol. 1989 Nov 1;38(21):3743-51.