Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 30.7-51.9 min [1]
  Bioavailability: The bioavailability of drug is 88% [1]
  Clearance: The total body clearance of drug is 895-1361 mL/min [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 0.5 - 1 hours [2]
  Metabolism: The drug is metabolized via the creation of carbon dioxide and water through the Krebs cycle and secondarily by beta-oxidation []
  Vd: The volume of distribution (Vd) of drug is 37.7-67.7 L/kg [1]

References

• [1] Brenneisen R, Elsohly MA, Murphy TP, Passarelli J, Russmann S, Salamone SJ, Watson DE: Pharmacokinetics and excretion of gamma-hydroxybutyrate (GHB) in healthy subjects. J Anal Toxicol. 2004 Nov-Dec;28(8):625-30.
• [2] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds