Details of the Drug

General Information of Drug (ID: DMCT6QW)

Drug Name	Pyrazolo[1,5-a]pyrimidine derivative 29
Synonyms	PMID25470667-Compound-Figure5-18
Drug Type	Small molecular drug
Structure
Structure	3D MOL	2D MOL
#Ro5 Violations (Lipinski): 0	Molecular Weight (mw)	291.35
	Logarithm of the Partition Coefficient (xlogp)	2.5
	Rotatable Bond Count (rotbonds)	3
	Hydrogen Bond Donor Count (hbonddonor)	1
	Hydrogen Bond Acceptor Count (hbondacc)	3
Chemical Identifiers	Formula C17H17N5 IUPAC Name 6-(1-propylindol-5-yl)pyrazolo[1,5-a]pyrimidin-7-amine Canonical SMILES CCCN1C=CC2=C1C=CC(=C2)C3=C(N4C(=CC=N4)N=C3)N InChI InChI=1S/C17H17N5/c1-2-8-21-9-6-13-10-12(3-4-15(13)21)14-11-19-16-5-7-20-22(16)17(14)18/h3-7,9-11H,2,8,18H2,1H3 InChIKey WYJQPMFWZLKCBR-UHFFFAOYSA-N
Cross-matching ID	PubChem CID 74221584 TTD ID D0XT7O

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Diacylglycerol acyltransferase 1 (DGAT1)	TTF8P9I	DGAT1_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Diacylglycerol acyltransferase 1 (DGAT1)	DTT	DGAT1	3.51E-01	-0.41	-0.62

Molecular Expression Atlas (MEA)

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References

1	Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.