Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1-3 h [1]
  Elimination: In a radiolabeled drug study, approximately 59% of the radiolabeled dose was recovered in feces, in which 54% of that amount was in the unchanged parent drug form [1]
  Half-life: The concentration or amount of drug in body reduced by one-half in 60 - 70 hours [2]
  Metabolism: The drug is metabolized via the CYP3A4 [1]
  Vd: The volume of distribution (Vd) of drug is 6304 L [1]

References

• [1] FDA Approved Drug Products: GEMTESA (vibegron) tablets, for oral use
• [2] Evaluating vibegron for the treatment of overactive bladder. Expert Opin Pharmacother. 2020 Sep 29:1-9. doi: 10.1080/14656566.2020.1809652.