Details of the Drug

General Information of Drug (ID: DMDMNJ6)

Drug Name

Anti-HER3/EGFR DAF

Indication

Disease Entry	ICD 11	Status	REF
Metastatic epithelial tumour	2D60	Phase 1	[1]
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Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Epidermal growth factor receptor (EGFR)	TTGKNB4	EGFR_HUMAN	Modulator	[2]
Erbb3 tyrosine kinase receptor (Erbb-3)	TTDC8N2	ERBB3_HUMAN	Modulator	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Metastatic epithelial tumour

ICD Disease Classification

2D60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Epidermal growth factor receptor (EGFR)	DTT	EGFR	5.84E-05	0.32	0.55

Molecular Expression Atlas (MEA)

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References

1	Clinical pipeline report, company report or official report of Genentech (2011).
2	Company report (Biooncology)