Details of the Drug

General Information of Drug (ID: DMDSKR2)

• Drug Name: CAR-T cells targeting Glypican-3 (GPC3)

Indication

Disease Entry	ICD 11	Status	REF
Hepatocellular carcinoma	2C12.02	Phase 1/2	[1]

• Drug Type: CAR T Cell Therapy
• Cross-matching ID: TTD ID: D0WN2Y

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glypican-3 (GPC3)	TTJTSX4	GPC3_HUMAN	CAR-T-Cell-Therapy	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Hepatocellular carcinoma
• ICD Disease Classification: 2C12.02

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glypican-3 (GPC3)	DTT	GPC3	5.54E-86	3	9.74

References

• [1] ClinicalTrials.gov (NCT02723942) CAR-T Cell Immunotherapy for HCC Targeting GPC3