Details of the Drug

General Information of Drug (ID: DMEYR4K)

Drug Name

BMS-906024

Synonyms

1401066-79-2; UNII-DRL23N424R; BMS 906024; DRL23N424R; (2R,3S)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide; SCHEMBL12543868; DTXSID30161234; CHEBI:131164; ZINC100285156; SB16893; DB12006; KB-145938; Z-3229; BMS-906024, > Butanediamide, N1-((3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2R,3S)-

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]
Lymphoma	2A80-2A86	Phase 1	[2]
T-cell acute lymphocytic leukaemia	2B33.4	Phase 1	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C26H26F6N4O3
Canonical SMILES: CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
InChI: 1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1
InChIKey: AYOUDDAETNMCBW-GSHUGGBRSA-N

Cross-matching ID

PubChem CID: 66550890
ChEBI ID: CHEBI:131164
CAS Number: 1401066-79-2
TTD ID: D0O3CX

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT03691207) A Study Of AL101 In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations (ACCURACY). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT01292655) Study to Evaluate the Safety and Tolerability of IV Doses of BMS-906024 in Subjects With Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.