Details of the Drug

General Information of Drug (ID: DMFEUMZ)

• Drug Name: US8481586, 15
• Synonyms: CHEMBL575336; SCHEMBL844646; BDBM50299246; 7-Bromo-1,10-dihydropyrrolo[2,3-a]carbazole; US8481586, 15
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 285.14
  Logarithm of the Partition Coefficient (xlogp); 4.2
  Rotatable Bond Count (rotbonds); 0
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 0
• Chemical Identifiers:
  Formula: C14H9BrN2
  IUPAC Name: 7-bromo-1,10-dihydropyrrolo[2,3-a]carbazole
  Canonical SMILES: C1=CC2=C(C3=C1C=CN3)NC4=C2C=C(C=C4)Br
  InChI: InChI=1S/C14H9BrN2/c15-9-2-4-12-11(7-9)10-3-1-8-5-6-16-13(8)14(10)17-12/h1-7,16-17H
  InChIKey: JRPUZUBQJFQSQO-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 44479463
  TTD ID: D06TGF

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PIM-3 protein kinase (PIM3)	TTCGOIN	PIM3_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
PIM-3 protein kinase (PIM3)	DTT	PIM3	7.86E-06	0.78	3.44

References

• [1] Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586.