General Information of Drug (ID: DMFKXMT)

Drug Name
BW-202W92
Synonyms
BW-202W92; SCHEMBL136398; CHEMBL448556; QEDNOUAODRFJQN-UHFFFAOYSA-N; BW202W92; 2.4-Diamino-5-(2,3,5-trichlorophenyl)-6-fluoromethylpyrimidine; 2,4-diamino-5-(2,3,5-trichlorophenyl)-6-fluoromethylpyrimidine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 321.6
Logarithm of the Partition Coefficient (xlogp) 3.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C11H8Cl3FN4
IUPAC Name
6-(fluoromethyl)-5-(2,3,5-trichlorophenyl)pyrimidine-2,4-diamine
Canonical SMILES
C1=C(C=C(C(=C1C2=C(N=C(N=C2N)N)CF)Cl)Cl)Cl
InChI
InChI=1S/C11H8Cl3FN4/c12-4-1-5(9(14)6(13)2-4)8-7(3-15)18-11(17)19-10(8)16/h1-2H,3H2,(H4,16,17,18,19)
InChIKey
QEDNOUAODRFJQN-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9883607
TTD ID
D0B9UU

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Inhibitor [1]
Voltage-gated sodium channel alpha Nav1.3 (SCN3A) TTAXZ0K SCN3A_HUMAN Inhibitor [1]
Voltage-gated sodium channel alpha Nav1.4 (SCN4A) TT84DRB SCN4A_HUMAN Inhibitor [1]
Voltage-gated sodium channel alpha Nav1.8 (SCN10A) TT90XZ8 SCNAA_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707.