Details of the Drug

General Information of Drug (ID: DMFQERG)

• Drug Name: US9340511, 5
• Synonyms: SCHEMBL523724; CHEMBL3970151; JPXYINYXIDIDQY-UHFFFAOYSA-N; BDBM227556; US9340511, 5; 2-[4-hydroxy-1-methyl-7-(4-methoxy-phenoxy)-isoquinoline-3-carboxamido]acetic acid
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 382.4
  Topological Polar Surface Area (xlogp); 3.4
  Rotatable Bond Count (rotbonds); 6
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 7
• Chemical Identifiers:
  Formula: C20H18N2O6
  IUPAC Name: 2-[[4-hydroxy-7-(4-methoxyphenoxy)-1-methylisoquinoline-3-carbonyl]amino]acetic acid
  Canonical SMILES: CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=C(C=C3)OC
  InChI: InChI=1S/C20H18N2O6/c1-11-16-9-14(28-13-5-3-12(27-2)4-6-13)7-8-15(16)19(25)18(22-11)20(26)21-10-17(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
  InChIKey: JPXYINYXIDIDQY-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 11440448
  TTD ID: D0LO2C

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]

References

• [1] Process for making isoquinoline compounds. US9708269.
• [2] Crystalline forms of a prolyl hydroxylase inhibitor. US9115085.
• [3] Partially saturated nitrogen-containing heterocyclic compound. US9422240.
• [4] Prolyl hydroxylase inhibitors and methods of use. US9598370.
• [5] Prolyl hydroxylase inhibitors. US8536181.
• [6] Prolyl hydroxylase inhibitors and method of use. US8722895.
• [7] Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412.
• [8] Prolyl hydroxylase inhibitors and methods of use. US8598210.
• [9] Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170.
• [10] Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051.