Details of the Drug

General Information of Drug (ID: )

• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw)
  Logarithm of the Partition Coefficient (xlogp)
  Rotatable Bond Count (rotbonds)
  Hydrogen Bond Donor Count (hbonddonor)
  Hydrogen Bond Acceptor Count (hbondacc)
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 30-60 min [1]
  Bioavailability: The bioavailability of drug is 4% [1]
  Clearance: The total body clearance of drug is 161 L/h []
  Elimination: Boceprevir is mainly eliminated in the feces (79%) with a small amount eliminated in the urine (9%) []
  Half-life: The concentration or amount of drug in body reduced by one-half in 3.4 hours []
  Metabolism: The drug is metabolized via the aldo-ketoreductase-mediated pathway []
  Vd: The volume of distribution (Vd) of drug is 772 L []

References

• [1] NORPROLAC? (quinagolide) Product information