Details of the Drug

General Information of Drug (ID: DMG7PDY)

Drug Name

XEN-D0501

Synonyms

XEN-D501; Ion channel modulator 1 (overactive bladder), Xention; TRPV1 antagonist (overactive bladder), Xention;VR1 antagonist (overactive bladder), Xention; Vanilloid receptor-1 antagonist (overactive bladder), Xention; Ion channel modulator (overactive bladder), Xention/Scion/Bristol-Myers Squibb

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Phase 2	[1]
------------------------------------------------------------------------------------

Cross-matching ID

TTD ID: D04VQH

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Antagonist	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT02233699) A Study to Assess the Efficacy of XEN-D0501 in Reducing the Cough Frequency in Patients With Chronic Idiopathic Cough. U.S. National Institutes of Health.
2	An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31.