Details of the Drug

General Information of Drug (ID: DMG9OBA)

Drug Name

NI-1401

Synonyms

Anti-interleukin-17 MAb, NovImmune

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Investigative	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin 17 receptor (IL17R)	TT69OHW	I17RA_HUMAN ; I17RB_HUMAN ; I17RC_HUMAN ; I17RD_HUMAN ; I17RE_HUMAN	Not Available	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Autoimmune diabetes

ICD Disease Classification

5A10

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin 17 receptor (IL17R)	DTT	IL17RA; IL17RB; IL17RC; IL17RD; IL17RE	3.40E-10	-0.23	-0.72

Molecular Expression Atlas (MEA)

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294).