Details of the Drug

General Information of Drug (ID: DMGPQ0Y)

Drug Name

T-1105

Synonyms

3-Hydroxypyrazine-2-carboxamide; 55321-99-8; 2-oxo-1H-pyrazine-3-carboxamide; 3-Oxo-3,4-dihydropyrazine-2-carboxamide; Pyrazinecarboxamide, 3,4-dihydro-3-oxo-; NSC163503; SZPBAPFUXAADQV-UHFFFAOYSA-N; Pyrazine-2-carboxamide, 3-hydroxy-; t6mv dnj cvz[wln]; 3-HYDROXYPYRAZINE-2-CARBOXAMINE; AC1Q6FTJ; AC1L6MD7; KSC273I6F; SCHEMBL1338425; ZINC8657; 3-Hydroxy-2-pyrazinecarboxamide; CTK1H3462; DTXSID10203888; 3-hydroxy-pyrazine-2-carboxamide; MolPort-005-980-549; 3-Hydroxy-2-pyrazinecarboxamide #

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

139.11

Logarithm of the Partition Coefficient (xlogp)

-0.9

Rotatable Bond Count (rotbonds)

1

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

3

Chemical Identifiers

Formula: C5H5N3O2
IUPAC Name: 2-oxo-1H-pyrazine-3-carboxamide
Canonical SMILES: C1=CN=C(C(=O)N1)C(=O)N
InChI: InChI=1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10)
InChIKey: SZPBAPFUXAADQV-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 294642
CAS Number: 55321-99-8
TTD ID: D09VHW

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Virus RNA-dependent RNA polymerase (Viru RdRP)	TTSUKYD	POLG_HCVJA	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.