Details of the Drug

General Information of Drug (ID: DMGZHRT)

• Drug Name: Aryl carbamate analog 1
• Synonyms: PMID26882240-Compound-19
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 377.4
  Logarithm of the Partition Coefficient (xlogp); 3.1
  Rotatable Bond Count (rotbonds); 6
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C21H19N3O4
  IUPAC Name: [4-hydroxy-3-(pyridin-3-ylmethylcarbamoyl)phenyl] N-methyl-N-phenylcarbamate
  Canonical SMILES: CN(C1=CC=CC=C1)C(=O)OC2=CC(=C(C=C2)O)C(=O)NCC3=CN=CC=C3
  InChI: InChI=1S/C21H19N3O4/c1-24(16-7-3-2-4-8-16)21(27)28-17-9-10-19(25)18(12-17)20(26)23-14-15-6-5-11-22-13-15/h2-13,25H,14H2,1H3,(H,23,26)
  InChIKey: DSHOFHQFNJBXHY-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 71541820
  TTD ID: D0RT4U

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hypoxia-inducible factor 1 (HIF-1)	TTUX68I	NOUNIPROTAC	Inhibitor	[1]

References

• [1] Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22.