Details of the Drug

General Information of Drug (ID: DMH3E5C)

Drug Name

TMB-365

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Phase 1	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
T-cell surface glycoprotein CD4 (CD4)	TTN2JFW	CD4_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Human immunodeficiency virus-1 infection

ICD Disease Classification

1C62

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
T-cell surface glycoprotein CD4 (CD4)	DTT	CD4	9.36E-04	0.67	2.62

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT04027387) Dose Escalation Safety Study of TMB-365 in HIV-1 Infected Participants. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of TaiMed Biologics.