Details of the Drug

General Information of Drug (ID: DMH7DL5)

• Drug Name: US9422240, 1-298
• Synonyms: SCHEMBL16761969; CHEMBL3899583; BDBM242556; US9422240, 1-298
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 465.4
  Logarithm of the Partition Coefficient (xlogp); 3
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 10
• Chemical Identifiers:
  Formula: C21H18F3N3O6
  IUPAC Name: 2-[[4-hydroxy-6-oxo-1-[[4-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]-2,3-dihydropyridine-5-carbonyl]amino]acetic acid
  Canonical SMILES: C1CN(C(=O)C(=C1O)C(=O)NCC(=O)O)CC2=CC=C(C=C2)OC3=NC=C(C=C3)C(F)(F)F
  InChI: InChI=1S/C21H18F3N3O6/c22-21(23,24)13-3-6-16(25-9-13)33-14-4-1-12(2-5-14)11-27-8-7-15(28)18(20(27)32)19(31)26-10-17(29)30/h1-6,9,28H,7-8,10-11H2,(H,26,31)(H,29,30)
  InChIKey: OAYSSFWXQZDVKQ-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 73050969
  TTD ID: D00CAO

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase 2 (HPH-2)	TT9ISBX	EGLN1_HUMAN	Inhibitor	[1]

References

• [1] Partially saturated nitrogen-containing heterocyclic compound. US9422240.