Details of the Drug

General Information of Drug (ID: DMHVIZC)

Drug Name
NN-7415
Synonyms NNC-0172-0000-2021
Indication
Disease Entry ICD 11 Status REF
Factor IX deficiency 3B11 Phase 1 [1]
Cross-matching ID
TTD ID
D0U0XL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tissue factor pathway inhibitor (TFPI) TT068JH TFPI1_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Factor IX deficiency
ICD Disease Classification 3B11
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tissue factor pathway inhibitor (TFPI) DTT TFPI 1.27E-08 0.14 0.84
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT01228669) Safety of NNC 0172-0000-2021 in Healthy Male Subjects and Subjects With Haemophilia A or B. U.S. National Institutes of Health.
2 Safety and pharmacokinetics of anti-TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial.J Thromb Haemost.2015 May;13(5):743-54.