Details of the Drug

General Information of Drug (ID: DMIAZJ9)

Drug Name
RhApo2L/TRAIL
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1/2 [1]
Cross-matching ID
TTD ID
D08JRT

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TRAIL receptor 1 (TRAIL-R1) TT5WLRX TR10A_HUMAN Agonist [2]
TRAIL receptor 2 (TRAIL-R2) TTW20TU TR10B_HUMAN Agonist [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TRAIL receptor 2 (TRAIL-R2) DTT TNFRSF10B 1.03E-05 1.09 4.71
TRAIL receptor 1 (TRAIL-R1) DTT TNFRSF10A 4.44E-01 0.13 0.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011860)
2 Clinical pipeline report, company report or official report of Amgen (2009).