Details of the Drug

General Information of Drug (ID: DMIUPSA)

Drug Name	1,2,4-triazolo[1,5a]pyridine derivative 1
Synonyms	PMID27774824-Compound-Figure8compoundA
Drug Type	Small molecular drug
Structure	3D Structure is Not Available
Structure	3D MOL	2D MOL
Cross-matching ID	TTD ID D07XYI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Focal adhesion kinase 1 (FAK)	TTON5IT	FAK1_HUMAN	Inhibitor	[1]
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Inhibitor	[1]
Janus kinase 3 (JAK-3)	TTT7PJU	JAK3_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Janus kinase 3 (JAK-3)	DTT	JAK3	4.94E-03	0.28	1.41
Janus kinase 2 (JAK-2)	DTT	JAK2	9.53E-04	0.27	1.44

Molecular Expression Atlas (MEA)

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References

1	Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143.